Assessing quality of life in clinical trials.

• Complete revision and update to cover the increased breadth and importance of the field of QoL measurement • A rigorous, broad comprehensive coverage of all aspects of QoL measurement, methods and practice • Gives a new focus on qualitative methods which have become considerably more advanced and now have a stronger scientific basis • Introduces Rasch models and item response theory, the use of which has grown considerably • Includes detailed discussion of analytical techniques highlighting the value of new available software for analysis • Provides an in depth discussion of interpreting results and the ongoing discussions about issues such as individualized measures